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Euclises Pharmaceuticals is developing and testing novel cyclooxygenase-2 (COX-2, an enzyme responsible for inflammation and pain) inhibitors designed to increase the anti-cancer potency and effectiveness of chemotherapy safely, offering new treatment options for patients suffering from colorectal, non-small cell lung and pancreatic cancers.
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Zumbro Discovery is a biotech company developing novel peptides for the treatment of resistant hypertension (RH), a condition characterized by a combination of cardiovascular, kidney and adrenal gland complications. RH is an indication with no approved drugs that affects 12% of US hypertensives, or 9 million Americans, and an estimated 300 million people worldwide.
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Entac Medical is developing noninvasive devices for predictive and diagnostic medicine based on a novel, patented, platform technology, Previs Audio Spectral Analysis Technology (PASAT). The first application, PrevisEA, is a noninvasive, disposable, self-contained device that is clinically proven to predict postoperative ileus (POI) in surgical patients.
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Agrible sells software that connects the agricultural supply chain from field-to-market, providing critical sustainability, agronomic, and yield data. In an era when consumers demand to know what is grown (e.g., GMO vs non-GMO) and how it is grown (e.g., sustainable, organic, etc.), Agrible is the only solution that provides verifiable visibility from what goes in the ground to what goes in the package, with implications on how agricultural products are grown, traded, transported, processed, and labeled.
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Holganix produces and sells 100% organic plant probiotics that significantly reduce the need for fertilizers, herbicides, pesticides, fungicides and water while improving plant vibrancy and yield.
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ProteoSense is commercializing a proprietary biosensor for food safety testing. Current tests require expensive, specialized equipment and personnel, take anywhere from 12-hours to days, and often require food to be placed on hold until results are available. ProteoSense's high-sensitivity, portable system detects foodborne pathogens in less than 2-hours, reducing test time from days to minutes, an important distinction for perishable foods with a limited shelf life.
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Prior Funding Rounds Closed

Cofactor Genomics uses proprietary RNA sequencing technology and machine learning algorithms to diagnose disease. RNA serves as a real-time barometer of a person's health, as opposed to DNA which remains little changed throughout a person's life and whose analysis is estimated to diagnose less than 5% of diseases. Compared to current methods, Cofactor's patent pending RNA isolation technology allows the Company to detect specific RNA molecules from low-quality tissue samples, making 100x more patient specimens available for analysis.
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Indalo Therapeutics (formerly known as Antegrin Therapeutics, Inc.), based in St. Louis, MO is a biopharmaceutical company developing and testing novel compounds that inhibit the development of pulmonary (lung) fibrosis and other fibrotic diseases by inhibiting proteins that are the key drivers of the fibrotic process. Uncontrolled, fibrosis can cause diseased organs to stop functioning.
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PopBookings, Inc. develops software that streamlines the temporary employment market. With an initial focus on the highly fragmented, $2.2 billion event-staffing segment, the Company's cloud-based and mobile-enabled software automates the hiring, scheduling, attendance, payroll, and performance reporting processes for both employers and 1099 employees.
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Benson Hill Biosystems, Inc., based in Durham, NC, with offices in St. Louis, MO, is an agricultural biotechnology company focused on the development of traits to increase intrinsic crop yield, principally by enhancing photosynthetic efficiency. By combining cloud computing, data analytics and plant biology, Benson Hill's CropOS™ is a cognitive engine that provides decision support to increase productivity, improve resource utilization and enhance the nutritional properties of crops.
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Gila is developing a treatment for obesity using naturally occurring hormones (PYY) known to induce satiety, leading to weight loss. Gila is developing formulations to be applied to the tongue prior to meals, which have successfully induced satiety in animal testing without causing the nausea like symptoms associated with injectable and other formulations.
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FairWords automates manual governance processes, using a novel AI-driven platform to automatically review electronic communications going in and out of a company. FairWords' technology saves time and mitigates risk by helping to assure a culture of compliance.
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More than just an energy dashboard, the Bractlet platform provides real time analytics, highly predictive forecasts, and continuous, automated energy saving measure identification and ROI analysis for individual buildings and portfolios. Bractlet collects real-time environmental, building- level and equipment-level data, and combines with physics-based simulation technology for a comprehensive approach that allows us to find, forecast, and verify the most effective savings measures.
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Kultevat, Inc., based in St. Louis, MO, combines genetic breeding and chemical process engineering to produce natural rubber from Russian dandelions. There is a strong need to develop a domestic source of natural rubber. Russian dandelions can be grown across wide swaths of the U.S., and produce rubber that matches the characteristics of rubber derived from rubber trees.
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Neuros Medical, Inc., a Cleveland, Ohio based neuromodulation company, is focused on developing proprietary therapies for unmet needs to patients worldwide. The company's patented platform technology, Altius® Electrical Nerve Block, is focused on elimination of chronic pain in a variety of applications including neuroma/residual limb pain, chronic post-surgical pain, and chronic migraine.
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StreamLink, Inc., based in Cleveland, OH, sells software as a service (SaaS) solutions to nonprofit and public sector entities. StreamLink's Amplifund software enables federal grant recipients to meet the new accounting and reporting requirements of the U.S. Data Act of 2014 regarding their use of grant funds. Its BoardMax software provides a centralized environment for all board of directors-related information and documents.
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Euclises Pharmaceuticals is developing and testing novel cyclooxygenase-2 (COX-2, an enzyme responsible for inflammation and pain) inhibitors designed to increase the anti-cancer potency and effectiveness of chemotherapy safely, offering new treatment options for patients suffering from colorectal, non-small cell lung and pancreatic cancers.
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BetterWeekdays, Inc., based in St. Louis, MO, provides a job-matching platform that helps colleges and universities improve job placement outcomes for their graduates and helps employers hire better-qualified candidates based on individual skills and business culture fit. Its software automatically collects and generates more than 1 million live job opportunities and personalizes them to students on their mobile devices, tracking all activity for accreditation and compliance reporting.
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Systematic Revenue, LLC dba Hatchbuck, based in St. Louis, MO, provides all-in-one sales and marketing software designed especially for small to mid-sized businesses. Through its SaaS platform, Hatchbuck combines CRM, email marketing and marketing automation solutions directly to customers by subscription and indirectly through advertising agencies.
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Rewards Catering, LLC dba Time to Cater, based in St. Louis, MO, is a web-based full service national catering concierge service used to organize and coordinate catered events from small meetings to multi-location national events. Event hosts enter location, time, attendance and budget information through Time to Cater's free-to-use website and Time to Cater manages the rest.
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Gremln, Inc., based in St. Louis, MO, provides secure social media software for financial service and other regulated industries. Its software combines social media marketing, customer service, monitoring, and the approval processes, filtration and archiving necessary for regulatory compliance (SEC, FINRA, FFIEC), meeting the needs of both a financial services firm’s marketing and compliance departments.
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CrazyForEducation, LLC, based in St. Louis, MO, provides an online database of educational and tutoring programs that teachers and students can access as part of a "Flip classroom;" that is, one in which lecturing occurs primarily outside the classroom while tutoring (homework) is done inside the classroom.
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Tansna Therapeutics, Inc., based in St. Louis, MO, is developing and testing anticonvulsant drugs for the treatment of epilepsy. Worldwide, at least 50 million people suffer from epilepsy, 30% of whom are unable to achieve adequate seizure control using existing medications. Tansna's proprietary anticonvulsant compounds have been shown in animal testing to prevent seizures in such otherwise therapy-resistant patients.
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