Alzheimer's Disease: Therapeutics

Alzheimer’s Disease: Therapeutics

Alzheimer’s Disease (AD) poses significant challenges on individual, family, and health system levels, with the highest drug development failure rate among diseases currently being studied. However, researchers continue to explore new pathways for optimizing drug development, clinical trial recruitment, and understanding disease pathogenesis. As AD is a multifactorial disease, the solutions to therapeutic development must be multifaceted as well. In this week’s Alzheimer’s Disease Therapeutics Deep Dive, we explore the current state of AD therapeutics development, the latest cutting-edge research, and the major challenges faced today.

In our AD Therapeutics Deep Dive, we delve into the various factors contributing to the high failure rate of drug development for Alzheimer’s Disease and the reasons behind it. Learn about the complexities of the disease and the challenges in identifying effective therapies, from understanding the genetic and environmental factors to developing accurate diagnostic tools and biomarkers.

Discover the innovative approaches being taken by researchers and pharmaceutical companies to overcome these hurdles. Gain insights into the latest advancements in the field, such as targeting amyloid-beta, tau protein, and neuroinflammation, as well as exploring novel therapeutic targets and strategies, including gene therapy, stem cell therapy, and personalized medicine.

Hear from renowned experts in Alzheimer’s research, who share their perspectives on the current state of AD therapeutics development and the direction in which the field is headed. Understand the importance of collaboration between academia, industry, and regulatory bodies to accelerate the development of effective treatments for Alzheimer’s Disease.

Learn about the role of clinical trials in AD drug development and the efforts to improve trial recruitment, design, and efficiency. Find out how the global research community is working together to overcome the challenges in AD therapeutics development and move towards a brighter future for those affected by this devastating disease.

Watch our Alzheimer’s Disease Therapeutics Deep Dive to stay informed on the latest research, breakthroughs, and challenges in the quest for effective treatments for Alzheimer’s Disease.

Additional Resources

TRANSCRIPT

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Analyst: David Yocom

Our analyst team reviews an emerging trend with interested listeners — alternating between Healthcare and Agriculture — outlining macro-trends, industry sub-sectors, key influencers, market leaders, and potential investment opportunities. Register here.

Consideration

With 2021 well underway and with public markets still strong, we think it is an important time to highlight some of the key private market, venture investment themes that iSelect fund has identified for the year. We believe technologies transforming the Agriculture, Food and Wellness markets will flourish, with a focus on four areas: technologies that enable better food choices to drive better health outcomes, technologies that drive better, more profitable farm operations, technologies that drive the Consumerization of Healthcare, and biome-based treatment technologies. At iSelect, we invest for impact AND performance. We offer qualified investors access to emerging growth companies through our national venture capital strategy. Our unique structure allows our investors to continue to invest in these companies as they develop.

Timing

Why is now the right time for venture? The answer is that now is not explicitly the right time. Venture is something we need in our economy at all times. Now is not better than any other particular time. The question is, why ever stop? When we look at the challenges we’re facing in food and healthcare the reality is there is someone, somewhere who has an insight about how to build a product that will solve those problems. And if they put the right resources to it, they will succeed. As long as we need new technology to make life better or make our lives more enjoyable, we need venture capital to help fuel those entrepreneurs.

What is iSelect as a product?

iSelect is a very unique product, but when you break it into its parts it’s fairly easy to understand. On the front end we’re a traditional venture capital fund. We have a diligence process. We have an investment process. We have categories of industries where we have focus and real expertise, and we invest in companies in those areas that meet requirements for the fund. On the back end we’re unique in that we don’t raise a large amount of capital at one time and deploy it over the life of our fund. Each deal that we bring onto the fund, our investors have to prove and determine to invest in that deal. We have to constantly prove our diligence standards. It’s accessible, transparent and easy for investors to come in and see our comprehensive process.

What is the ideal iSelect company?

We are looking for founders that are passionate and we want the problem they’re trying to solve to be big, real, and painful. We want the solution to be revolutionary and we want our capital to be able to help them solve that problem. We want to know that they have customers involved and that the solution they’ve come up with actually meets those customers’ and market needs. And we want the team to be capital efficient with the money they’re spending.

What does the ideal iSelect company look like?

We’re looking for a company that has an opportunity to have a 10x return to our investment or greater in a period of three to seven years. What excites us at iSelect are companies that are solving big problems. We want companies that are going to be the Monsantos of the future. Not just in the size and the scope, but the impact they have on people’s lives. We want to create positive impacts on people’s lives, so we invest in areas like agricultural production and areas like producing healthy foods for our kids. They are problems that impact real people’s lives on a daily basis. That’s what we’re trying to do at iSelect. We’re trying to solve the big problems out there. Find ways to bring capital to the entrepreneurs who are the real heroes out there getting up every morning, beating away at these things that are problems that you and me and everyone else faces in their everyday lives.

What is iSelect?

iSelect is a venture capital firm. What that means is we look at hundreds and hundreds of different companies and we apply tough diligence standards to each of them, looking at whether the team has a good plan for growing the business, whether the team is qualified and credible, and more. We do that to resolve the few who provide the best opportunities for investors. And then iSelect takes that smaller set of investments and goes to investors who are interested in venture capital and provides a way for them to invest in these companies, either individually or all at once. We co-invest alongside other venture capitalists. We source transactions through to an exit where the company would become public or get bought. And we manage that whole investment process on behalf of our investors.